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Fetal exposure to abnormal androgen levels causes masculinization of female genitalia, with a spectrum of abnormalities that include clitoromegaly [Bachelot et al. However, further data are required to improve the CI Fig. It may be congenital or acquired and is usually due to an excess of androgens in fetal life, infancy, or adolescence. Involvement of the external genitalia is highly uncommon and mostly affects the clitoris and labia or extends to the urinary tract, especially the bladder. Submission Websites List.

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Besides malignant schwannoma, histological examination usually identifies solitary or plexiform neurofibroma. Turner syndrome is a female sex chromosome DSD that results from partial or complete loss of an X chromosome. It is performed in various ways and often includes clitoridectomy [Rouzi et al. The diagnosis relied on histopathological examination of the lesion, because it is difficult to distinguish between schwannoma and neurofibroma [Llaneza et al. In spite of its prevalence the pediatric literature is scanty. Download Download video in p quality 1. They are due to traumatic transplantation of the epidermis into intradermal or subcutaneous tissue with subsequent proliferation of epidermal cells [Schober et al.

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Androgen metabolite excretion tends to be low in patients older than 2 months of age, but it may be elevated in newborns at the time of sex differentiation, causing androgen production. The abnormality ultimately leads to increased subperiosteal bone matrix formation [Gazi et al. Besides a number of malformations, affected female infants commonly show hirsutism and clitoromegaly. It is congenital or acquired, most often as a result of exposure to an excess of androgens in fetal life, infancy, or adolescence. Its administration during gestation induced virilization of female fetuses characterized by clitoromegaly, fused labia, and urogenital sinus formation [Brunskill, ]. Beckwith-Wiedemann syndrome BWS is a constellation of congenital abnormalities and the most common overgrowth syndrome.

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Description: The latter syndrome covers a wide spectrum of undervirilization phenotypes including clitoromegaly Table 4. July Number of Print Pages. How can you rub clits on a subway train. In a study of families with type 1 neurofibromatosis, 4 patients had clitoral involvement, and in 3 of them the lesion was limited to the clitoris [Sutphen et al. We reviewed the literature on the conditions that may be involved in the development of clitoromegaly in childhood and adolescence. According to some authors, it originates from the skin overlying the pubic symphysis immediately superior to the base of the penis or clitoris and extending to but not communicating with the anterior wall of the bladder. Finally, type 4 involves mutations in the transcript release factor PTRF gene, which encodes a caveolar-associated protein required for the formation and localization of the caveolae and the correct function of polymerase I [Shastry et al. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor s. In one of these cases, a preterm baby girl received multiple blood transfusions from an adult man. Embryologically, the clitoris is homologous to the male penis.
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